In searching for over the counter UTI treatments (OTC), it doesn’t take long to discover that there are countless blogs, ads, and social media posts encouraging you to try [insert product name here].
But as you may have quickly learned, what helps one person prevent or manage their UTI symptoms may not be the best option for you. With so many OTC UTI treatments available, how do you determine which items you can trust?
In fact, the confusion around how to find high quality supplements – for anyone, not just people with recurrent or chronic UTI – is so vast that we wrote an ebook about this topic alone: How to Find High Quality Supplements.
Recommendations from our community and medical and nutritional advisors encouraged us to establish a collection of products that support pelvic and urinary tract health. One thing we’ve learned: Over the counter UTI treatments that demonstrate the most success always adhere to exceptional ingredient sourcing and manufacturing standards.
Here, you can gain a brief overview of these OTC UTI treatment ,prevention, and diagnostic products.
UTI affects more than 400 million people worldwide every year. We’ve developed this collection with that in mind. For any product that is not available in all regions, we’ve listed comparable products that are available globally.
You’ll notice that many over the counter UTI products are available via Femologist. They have a reputation for sourcing quality products backed by clinician recommendations, and they support the work we do.
Over the counter UTI treatments such as D-mannose and natural antimicrobials have been shown to be effective against organisms such as E. coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Candida. Some of the most effective and commonly used antimicrobials are laid out below.
Product Type | The Research Says . . . | Find It . . . |
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D-Mannose | >>> UTI prevention | Femologist Regions: D-Mannose Powder D-Mannose Tablets Global: Protocol for Life D-mannose |
Natural Antifungal | >>> Candida and biofilms | Femologist Regions: CandidaStat Global: CandidaStat |
Oregano Oil | >>> Prevent antibiotic resistance with oregano >>> Oregano vs. antifungal medications | Femologist Regions: D-Mannose Powder Global: Oreganol |
Elecampane and Jalap Root Extract | >>> Enula increases antibiotic efficacy | Femologist Regions: Enula |
Cryptolepis Sanguinolenta | >>> Effectiveness of cryptolepis | Femologist Regions: Crypto-Plus |
Product & Supportive Research | Find It |
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How D-Mannose may prevent UTI >>> | Find D-Mannose Powder Find D-Mannose Tablets |
How oregano can prevent antibiotic resistance >>> Is oregano more effective than antifungals? >>> | Find Oreganol |
How Enula increases the efficacy of antibiotics >>> | Find Enula |
Effectiveness of cryptolepis >>> | Find Cryptolepis |
Targeting Candida and biofilms with CandidaStat >>> | Find CandidaStat |
For a more comprehensive list, you can view a collection of natural antimicrobials recommended by Ruth Kriz, APRN.
A great amount of focus is placed on eradicating ‘bad’ bacteria. However, research indicates that the overall state of the urinary microbiome (and many other microbiomes of the body) is not only impacted by the amount of pathogenic bacteria present, but also by the amount of beneficial organisms – and the balance between them.
What’s more, due to the interconnectedness of the various microbiomes of the body, the health of the gut and vagina may influence the urinary microbiome. Quality probiotics aimed at balancing these microbiomes have the potential to reduce the risk of UTIs, decrease the risk of antibiotic resistance, and more.
![]() | "As a result of gut dysbiosis, an imbalance of certain gut microbes may transfer to the vagina and/or bladder and link to UTIs, e.g. E.coli."
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Recently, a new randomized, placebo-controlled study compared four methods of probiotic use for UTI prevention. Participants received a combination of oral and vaginal probiotics, with some participants receiving one or both of the products as a placebo.
Over 70% of participants who received both an oral and vaginal placebo had a UTI within four months. Participants who received both an oral and vaginal probiotic had only a 31.8% incidence of UTI at four months.
Product Type | The Research Says . . . | Find It . . . |
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Lactobacillus, Bifidobacterium, and other common probiotic strains | Probiotics may: >>> Reduce the risk of UTIs by 50% >>> Inhibit the growth of pathogens >>> Lower risk of antimicrobial resistance >>> Prevent side effects of antibiotics | Femologist Regions: PRO-Women: Probiotic & D-Mannose combo Ortho Biotic 100 for immune function Global: PRO-Women: Probiotic & D-Mannose Combo |
Soil-Based Organisms (SBO) | >>> Advantages of SBOs | Femologist Regions: CoreBiotic |
Prebiotic | >>> Prebiotics stimulate the growth of probiotics | Femologist Regions: MegaPre: Prebiotic Global: Hyperbiotics Prebiotic |
Product & Supportive Research | Find It |
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Lactobacillus, Bifidobacterium, and other common probiotic strains may: Reduce the risk of UTIs by up to 50% >>> Inhibit the growth of pathogenic organisms >>> Lower the risk of antibiotic resistance >>> Prevent or decrease side effects of antibiotics >>> | PRO-Women: Probiotic & D-Mannose Ortho Biotic 100: Probiotic immune support |
Advantages of Soil-Based Organisms (SBO) Probiotics >>> | CoreBiotic |
How prebiotics stimulate the growth of probiotics >>> | MegaPre: Prebiotic |
UTIs after sex is an experience many across the community share. We have some understanding of why sex increases the risk of UTI, such as:
With 79% of UTIs in premenopausal females occurring within 24 hours of sex, the importance of taking steps to prevent UTI after sex can’t be understated.
Because individual circumstances differ, UTIs may still occur after sex. But taking preventive steps can decrease the risk. For some, such as Juliet who struggled with UTIs after sex, establishing a prevention routine with OTC UTI treatment stopped the cycle.
Read Juliet’s remarkable story or view the UTI After Sex Prevention Bundle she developed alongside Femologist.
Product Type | The Research Says . . . | Find It . . . |
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Vaginal Probiotic Suppositories | >>> Probiotic suppositories can prevent the growth of harmful bacteria >>> How borax can eliminate candida >>> How berberine can eliminate candida | Femologist Regions: BiopHresh vaginal suppositories Global: Vitanica Yeast Arrest vaginal suppositories |
Ph-Balancing Lubricant & Moisturizer | >>> Importance of a healthy vaginal pH >>> Exposure to semen increases pH | Femologist Regions: BioNude Personal Lubricant Global: Emerita Personal Moisturizer |
Antimicrobial & Anti-inflammatory | >>> How berberine prevents and disrupts biofilm >>> How marshmallow root can prevent gram-positive infections >>> How Uva Ursi may prevent recurrent UTI | Femologist Regions: Cystistatin Global: Whitaker Nutrition Berberine Nature's Way Marshmallow Root Eclectiv Institute Uva Ursi |
Juliet’s UTI After Sex Prevention Bundle | >>> Read Juliet's story | Femologist Regions: UTI After Sex Prevention Support Bundle |
Wearable to Prevent UTI During Sex | >>> Barriers during sex can decrease vaginal microbiome imbalance Note: Research around this type of product does not yet exist. However, we do know that a decrease of fluid transmission decreases the risk of vaginal pH disruption. | US: Lorals for Protection - FDA approved Global: Lorals for Pleasure and Comfort |
Product & Supportive Research | Find It |
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Vaginal probiotics can prevent the growth of harmful bacteria >>> | BiopHresh vaginal suppositories |
The importance of a healthy vaginal pH >>> Exposure to semen increases vaginal pH >>> | BioNude Personal Lubricant |
Berberine prevents and disrupts biofilm >>> Marshmallow root can prevent gram-positive infections >>> Uva Ursi may prevent recurrent UTI >>> | Cystistatin: a blend of berberine, marshmallow root, and Uva Ursi |
Barriers during sex can decrease vaginal microbiome disruption >>> | Lorals for Protection - FDA approved Lorals for Pleasure & Comfort |
Note: Research around this type of product does not yet exist. However, we do know that a decrease of fluid transmission decreases the risk of vaginal pH disruption. |
Pelvic floor dysfunction can stem from a variety of factors, including mental, emotional and physical stress, such as UTI. Likewise, pelvic floor dysfunction can result in lower urinary tract symptoms (LUTS) and even result in UTI.
It’s easy to focus on strengthening the pelvic floor when experiencing LUTS, especially if incontinence is present. And clinicians who do not specialize in pelvic floor dysfunction often recommend kegel exercises. However, it is not uncommon for people with weak pelvic floor muscles to also struggle with tight pelvic floor muscles. In fact, the two often go hand-in-hand.
So while kegels may increase the strength of the pelvic floor, they can simultaneously cause excess pelvic floor tension. Without the guidance of a specialist, this can lead to further dysfunction and LUTS.
So, how can you address pelvic floor dysfunction if traditional kegels may be contraindicated?
Some physical therapists specialize in understanding and working with the pelvic floor. For many people who experience UTI or LUTS, they’ve experienced the benefits of working with a pelvic floor therapist. Like many others, Meaghan credits pelvic floor therapy as a turning point in her healing.
Pelvic floor therapy can be difficult to access depending on location and medical system. Fortunately, some pelvic floor therapists have transitioned to developing online programs, allowing access to expert guidance and community support no matter where you are.
Dr. Bri Grogan, PT, DPT, a leading voice in pelvic health and wellness, founded Vibrant Pelvic Health to expand her training and guided programs to anyone experiencing pelvic pain or LUTS, unrestricted by location.
When stress is encountered, the body and nervous system react. This can create a stress-pain cycle that may lead to tension in the pelvic floor. In addition to addressing stress present within the pelvic floor, Vibrant programs aim to minimize the stress-pain cycle within the body.
The combination of evidence-based research and personal feedback from clients and Dr. Bri’s personal experience with prolapse guided the development of these programs. Each program is unique to fit your individual needs, while containing the following elements:
Programs Available Globally | Program Benefits |
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BEGIN Mini-Course | Foundational steps to gently incorporate pelvic floor healing into your life |
Overcome Pelvic Pain for Women | 12-week guided program for females experiencing:
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Lift for Prolapse Relief | 5-week guided program for those who experience prolapse and the associated symptoms |
For graduates of Overcome and Lift, stay tuned to Vibrant Pelvic Health for updates on additional ways to work with Dr. Bri . |
Programs Available Globally | Program Benefits |
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BEGIN Mini-Course | Foundational steps to gently incorporate pelvic floor healing into your life |
Overcome Pelvic Pain for Women | 12-week guided program for females experiencing: - Pelvic pain - Painful sex - Constipation - LUTS |
Lift for Prolapse Relief | 5-week guided program for those who experience prolapse and the associated symptoms |
For graduates of Overcome and Lift, stay tuned to Vibrant Pelvic Health for updates on additional ways to work with Dr. Bri . |
1. In-clinic or at-home pelvic floor exercises may significantly improve LUTS
2. Up to one-third of women experience at least one pelvic floor disorder
3. How pelvic floor training can reverse bladder prolapse symptoms
4. Pelvic floor therapy may improve LUTS
Limited amounts of research exist that provide information about how certain environments affect the health of the vagina and vaginal microbiome. And virtually no research has been conducted that looks at how underwear influences risk of infections – unless you count a singular study that determined thongs do not increase the risk of UTI.
As we know, the vaginal and urinary microbiomes are intimately connected. So what impacts the vaginal microbiome may also affect the health of the urinary tract. Although solid research is unavailable, we can use what we know about how other environments influence bacteria to develop reasonable theories about how the items we wear may increase our risk of infection.
The Research Says . . . | What This Means | Find It . . . |
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Ventilation reduces moisture and bacterial growth | Ventilation and airflow help to reduce moisture, thereby decreasing bacterial growth. Clothing that restricts ventilation and continually exposes the vagina and urethra to moisture may increase the risk of vaginal dysbiosis or UTI. | Oya Moisture Wicking Clothing Moisture wicking leggings & shorts Available Globally |
Moist environments prolong bacterial survival | Conditions that expose the vagina and urethra to moisture for an extended period may lead to vaginal or urinary dysbiosis. This may include moisture due to:
| Modibodi Underwear For leaking For perspiration For periods For pregnancy Available: US, UK, EU, AU, NZ |
Product & Supportive Research | Find It |
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Moist environments prolong bacterial survival >>> This means that conditions that expose the vagina and urethra to moisture for an extended period may lead to vaginal or urinary dysbiosis. This may include moisture due to: - Urine leakage - Vaginal discharge - Sweat - Vaginal bleeding Products that do not effectively absorb fluids may encourage bacterial growth. | Modibodi underwear for leaking Modibodi underwear for perspiration Modibodi underwear for periods Modibodi underwear for pregnancy |
Ventilation reduces moisture and bacterial growth >> This means that ventilation and airflow help to reduce moisture, thereby decreasing bacterial growth. Clothing that restricts ventilation and continually exposes the vagina and urethra to moisture may increase the risk of vaginal dysbiosis or UTI. | Oya moisture wicking leggings |
Standard UTI tests have been shown to be an insufficient tool for ruling out UTI, with anywhere between 60% and 90% of standard cultures and dipsticks demonstrating a false negative result. For this reason, more enhanced testing methods have been developed.
Enhanced tests can improve the detection of certain types of organisms as well as identify multiple organisms, which may be imperative to diagnosing a polymicrobial infection or imbalance of the microbiome.
Additionally, since we know that other microbiomes of the body can both influence the health of the urinary microbiome itself and cause lower urinary tract symptoms, assessing the health of other environments can be insightful, at a minimum, and necessary at a maximum.
Test Type | The Research Says . . . | Find It . . . |
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Enhanced UTI Test | >>> Improved detection of UTI with PCR and NGS tests | Most Regions MicroGenDx US & Europe Mdxhealth US Emeritus UK Digital Microbiology by SBL |
Enhanced Vaginal Microbiome Test | >>> Disruption of the vaginal microbiome can increase UTI risk | US Evvy Most Regions MicroGenDx UK Digital Microbiology by SBL |
Enhance Test for Prostate Cancer Risk | >>> UTI can increase risk of prostate cancer >>> Prostate health can cause UTI and LUTS in males | US & Europe Mdxhealth |
Supportive Research | Find It |
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How PCR and NGS tests improve detection of UTI >>> | Emeritus (US) Digital Microbiology by SBL (UK) Mdxhealth (US & Europe) MicroGenDX (most regions) |
The importance of vaginal microbiome testing for UTI >>> | Evvy (US) Digital Microbiology by SBL (UK) MicroGenDX (most regions) |
UTI can increae risk of prostate cancer >>> Prostate health can cause UTI and LUTS in males >>> | Mdxhealth (US & Europe) |
This list of over the counter UTI treatment and prevention products is far from exhaustive. As the experience of UTI varies between individuals, needs of individuals and benefits of products may also vary.
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